CAR T Cell Therapy Has Shown Promising Result In Cancer Treatment

CAR T Cell Therapy

CAR T Cell Therapy is a customized immunotherapy that uses a patient’s cells to treat cancer. CAR T Cells are engineered to recognize and attack cancer cells while sparing healthy tissue.

A typical CAR T-cell therapy is made of a combination of fragments, or domains, from the heavy (H) and light chains of a lab-made antibody. These domains are connected via a flexible linker to form a single-chain variable fragment antibody (scFv) — the portion of the therapy that's responsible for binding to the tumor cell antigen. Each scFv has different characteristics that affect how well it binds to and recognizes its target.

CAR T Cell Therapy has been shown to have promising results in several clinical trials, and some types are already approved for use in the US. Using a process called T-cell transfer, providers extract a patient’s T cells and modify them in the laboratory with the addition of chimeric antigen receptors (CARs). These artificial molecules, which are not found naturally in the body, allow the modified T cells to recognize and destroy cancer cells.

The modified T cells are then infused back into the patient, where they continue to multiply and, guided by their engineered receptors, target and kill any cancer cells that match the targeted antigen. CAR T-cells are currently being used to treat a variety of blood cancers, including multiple myeloma, diffuse large B-cell lymphoma (DLBCL) after first relapse, and follicular lymphoma, as well as some solid tumors, such as glioblastoma and ovarian cancer. The goal of this type of immunotherapy is to harness the body's immune system to fight cancer. The T cells in the immune system are modified to recognize and target specific tumor antigens. These cells are then infused back into the patient, where they grow and multiply to help attack the cancer.

One of the challenges with this type of treatment is that the engineered cells can also recognize healthy tissue, which is often expressed at the same site as the targeted cancer antigen. That can trigger off-tumor toxicity, which is a potentially life-threatening side effect. Fortunately, this can be mitigated by carefully selecting the tumor antigen to target. Currently, patients with certain types of cancer, such as lymphoma, are the best candidates for CAR T Cell Therapy. Patients with solid tumors are less likely to respond, and there are only a few cases of CAR T-cell therapies being used to treat these cancers. A trial Srour is leading for advanced kidney cancer, however, is showing promise in this area.

 

Comments

Post a Comment

Popular posts from this blog

Epigenetics; A Study Of How Cells Control Gene Activity Without Changing DNA Sequence

Image
Epigenetics Epigenetics is a study of stable changes in cell function that do not involve alterations in the DNA sequence. It is the study of how behaviors and environment can cause changes that affect the way genes work. Unlike genetic changes, epigenetic changes are reversible and do not change the DNA sequence, but they can change the way the DNA sequence is read by the body. Epigenetics explains how early experiences can have lifelong impacts. The genes that children inherit from the parents (biological) provide information that guides their development. For instance, how tall they could eventually become or the kind of temperament they could have. Epigenetics processes also lead to individual differences in appearance, physiology, cognition, and behavior, the group of traits known as the phenotype. Epigenetic changes are necessary for typical development and health, but they can also cause disease. Epigenetic changes are responsible for human diseases, such as Prader-Willi
Read more

Regaining Mobility And Relieving Pain: The Revolution Of Knee Replacement Surgery

Image
Knee Replacement The human knee is a remarkable joint, responsible for bearing our body weight and enabling various complex movements. However, with age, injury, or certain medical conditions, the knee's function can deteriorate, leading to debilitating pain and reduced mobility. Knee replacement surgery has emerged as a groundbreaking medical procedure that has transformed the lives of millions of people worldwide. In this article, we will explore the evolution, benefits, advancements, and future prospects of knee replacement surgery. Knee Replacement surgery, also known as knee arthroplasty, was first performed in the 1960s. Over the decades, the procedure has undergone significant advancements in techniques, materials, and prosthetics. Initially, it was primarily used for elderly patients with severe arthritis, but its applications have expanded to include younger individuals with post-traumatic injuries or congenital defects.   Modern knee replacement surgeries can be ca
Read more

The Eyewear Market: Unveiling A Vision For Fashion And Function

Image
Eyewear Market In today's fast-paced world, eyewear has transcended its traditional purpose of providing vision correction and has emerged as a fashion statement, a symbol of personal style, and a reflection of individuality. The global eyewear market has witnessed remarkable growth over the years, driven by changing consumer preferences, increasing awareness about eye health, and advancements in technology. This article explores the dynamic landscape of the Eyewear Market , highlighting key trends, market players, and factors shaping its growth. Eyewear has come a long way from its humble origins. Initially, eyeglasses were primarily functional devices crafted to improve vision. However, with the passage of time, they have transformed into a fashion accessory that blends aesthetics with functionality. Today, eyewear encompasses a diverse range of products, including prescription glasses, sunglasses, contact lenses, and even smart glasses. The Global Eyewear Market Is Projecte
Read more